3 Result(s)
within
Odessa Schillaci
English
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Article
Open AccessTGS1 mediates 2,2,7-trimethyl guanosine cap** of the human telomerase RNA to direct telomerase dependent telomere maintenance
Pathways that direct the selection of the telomerase-dependent or recombination-based, alternative lengthening of telomere (ALT) maintenance pathway in cancer cells are poorly understood. Using human lung canc...
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Article
Open AccessSFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability
In vertebrates, the telomere repeat containing long, non-coding RNA TERRA is prone to form RNA:DNA hybrids at telomeres. This results in the formation of R-loop structures, replication stress and telomere inst...
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Article
Open AccessExosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity
The goal of this study was to understand if exosomes derived from high-metastatic cells may influence the behavior of less aggressive cancer cells and the properties of the endothelium. We found that metastati...
