7 Result(s)

Article

Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia

This study investigated long-term microenvironmental responses (oxygenation, perfusion, metabolic status, proliferation, vascular endothelial growth factor (VEGF) expression and vascularisation) to chronic hyp...

O Thews, T Wolloscheck, W Dillenburg, S Kraus, D K Kelleher… in British Journal of Cancer (2004)

Article

Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment

The effects of combined and simultaneously applied localised 43°C hyperthermia (HT) and an antivascular bacteriochlorophyll-serine-based photodynamic therapy (Bchl-ser-PDT) on tumour growth and several microen...

D K Kelleher, O Thews, A Scherz, Y Salomon, P Vaupel in British Journal of Cancer (2003)

Article

Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours

The possibility of enhancing aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) by simultaneous application of localised hyperthermia (HT) was evaluated. Treatments of rat DS-sarcomas included: (i) co...

D K Kelleher, J Bastian, O Thews, P Vaupel in British Journal of Cancer (2003)

Article

Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion

Isolated limb perfusion allows the direct application of therapeutic agents to a tumour-bearing extremity. The present study investigated whether the dihydropyridine-type Ca²⁺-channel blocker nifedipine could imp...

O Thews, M Hummel, D K Kelleher, B Lecher, P Vaupel in British Journal of Cancer (2002)

Article

Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: Role of oxygenation status and tumour size

The urokinase plasminogen activator system plays a central role in malignant tumour progression. Both tumour hypoxia and enhancement of urokinase plasminogen activator, urokinase plasminogen activator-receptor...

M Weinmann, O Thews, T Schroeder, P Vaupel in British Journal of Cancer (2002)

Article

Normo- and hyperbaric oxygenation of tumors: from bench to bedside

O Thews in Breast Cancer Research (2001)

Article

Disparate responses of tumour vessels to angiotensin II: tumour volume-dependent effects on perfusion and oxygenation

Perfusion and oxygenation of experimental tumours were studied during angiotensin II (AT II) administration whereby the rate of the continuous AT II infusion was chosen to increase the mean arterial blood pres...

O Thews, D K Kelleher, P Vaupel in British Journal of Cancer (2000)