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  1. No Access

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    Measuring In Vivo Protein Dynamics Throughout the Cell Cycle Using Microfluidics

    Studying the dynamics of intracellular processes and investigating the interaction of individual macromolecules in live cells is one of the main objectives of cell biology. These macromolecules move, assemble,...

    Roy de Leeuw, Peter Brazda, M. Charl Moolman… in The Bacterial Nucleoid (2017)

  2. Article

    Open Access

    Recent insights from in vitro single-molecule studies into nucleosome structure and dynamics

    Eukaryotic DNA is tightly packed into a hierarchically ordered structure called chromatin in order to fit into the micron-scaled nucleus. The basic unit of chromatin is the nucleosome, which consists of a shor...

    Orkide Ordu, Alexandra Lusser, Nynke H. Dekker in Biophysical Reviews (2016)

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    Article

    Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments

    Magnetic torque tweezers are used to directly measure the torsional stiffness of single molecules of bare DNA and RecA filaments.

    Jan Lipfert, Jacob W J Kerssemakers, Tessa Jager, Nynke H Dekker in Nature Methods (2010)

  4. No Access

    Article

    Real-time observation of DNA translocation by the type I restriction modification enzyme EcoR124I

    Type I restriction enzymes bind sequence-specifically to unmodified DNA and subsequently pull the adjacent DNA toward themselves. Cleavage then occurs remotely from the recognition site. The mechanism by which...

    Ralf Seidel, John van Noort… in Nature Structural & Molecular Biology (2004)