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Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

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  1. Article

    Open Access

    Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

    Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF ameliorates the symptoms of β-hemoglobinopathies and ...

    Steven Heshusius, Laura Grech, Nynke Gillemans, Rutger W. W. Brouwer… in Scientific Reports (2022)

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  2. Article

    Open Access

    Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B

    The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one during the first weeks of gestation (ε to γ), and the second ...

    Petros Papadopoulos, Athanassia Kafasi, Iris M. De Cuyper, Vilma Barroca… in Human Genomics (2020)

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  3. Article

    Open Access

    Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors

    Both tissue-specific and ubiquitously expressed transcription factors, such as Sp-family members, are required for correct development. However, the molecular details of how ubiquitous factors are involved in ...

    Jane Gilmour, Leigh O’Connor, Christopher P. Middleton… in Epigenetics & Chromatin (2019)

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