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Article
The Behavior of Low-Yield Point Corrugated Steel Plate Shear Walls in Strengthening RC Frames
Two types of corrugated steel plate shear walls, namely low-yield point (LYP) and convention, are investigated in terms of strengthening reinforced concrete (RC) frames. Within LYP corrugated steel plate shear...
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Article
Open AccessEquol: a metabolite of gut microbiota with potential antitumor effects
An increasing number of studies have shown that the consumption of soybeans and soybeans products is beneficial to human health, and the biological activity of soy products may be attributed to the presence of...
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Article
Open AccessClinical study on freehand of bicortical sacral screw fixation with the assistance of torque measurement device
Sacral screw loosening is a typical complication after internal fixation surgery through the vertebral arch system. Bicortical fixation can successfully prevent screw loosening, and how improving the rate of b...
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Article
Open AccessComparison of robot-assisted versus fluoroscopy-guided transforaminal lumbar interbody fusion (TLIF) for lumbar degenerative diseases: a systematic review and meta-analysis of randomized controlled trails and cohort studies
As an emerging technology in robot-assisted (RA) surgery, the potential benefits of its application in transforaminal lumbar interbody fusion (TLIF) lack substantial support from current evidence.
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Article
MicroRNA-361-5p Alleviates Leydig Cell Apoptosis and Promotes Cell Growth by Targeting PIAS1 in Late-Onset Hypogonadism
Late-onset hypogonadism (LOH) is an age-related syndrome characterized by deficiency of serum testosterone produced by Leydig cells. Previous evidence suggested that microRNA (miR)-361-3p can serve as a promis...
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Article
“Hel** Others Makes Me Feel Better”: Trait Gratitude, Resilience, and Hel** Behavior Improve Mental Health during a COVID-19 Lockdown
Throughout the entire COVID-19 pandemic, physical lockdown restrictions caused a rise in mental health issues such as anxiety, depression, and stress. During the pandemic, Chinese universities implemented “dor...
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Article
Correlation between axial symptoms and cervical sagittal alignment parameters in patients with two-level or three-level cervical spondylotic myelopathy: anterior cervcial discectomy and fusion versus hybird surgery
To comparatively analyze the correlation between axial symptoms (AS) and cervical sagittal alignment parameters after anterior cervical discectomy and fusion (ACDF) and hybrid surgery (HS).
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Article
The serial mediation role of parent-child attachment and empathy in the relationship between parental technoference and social anxiety
The interference in parent-child interactions (i.e., parental technoference) has become an increasingly common type of parental neglect with the recent advancements in technology. Although literature has linke...
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Article
Open AccessComprehensiveness cuproptosis related genes study for prognosis and medication sensitiveness across cancers, and validation in prostate cancer
Cuproptosis-related genes (CRGs) are important for tumor development. However, the functions of CRGs across cancers remain obscure. We performed a pan-cancer investigation to reveal the roles of CRGs across ca...
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Article
Open AccessEffects of miR-214 on adenosine A2A receptor and carboxymethyl chitosan nanoparticles on the function of keloid fibroblasts and their mechanisms
This work prepared and investigated the impact of carboxymethyl chitosan nanoparticles (MC-NPs) on the proliferative capability of keloid fibroblasts (KFBs) while analyzing the mechanistic roles of miR-214 and...
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Article
The relationship between stressful childhood environments and depression for Chinese adolescents: a serial mediation model through perceived discrimination and belief in a just world
Stressful childhood environments influence mental health and well-being in adults and adolescents, but there is relatively limited evidence on how environmental unpredictability and harshness in early life are...
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Article
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...
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Article
Open AccessA concave four-arc honeycomb with enhanced stiffness and desirable negative Poisson’s effect
The conventional star-shaped honeycomb (CSSH) structure is inherently rich in mechanical properties. Based on the CSSH structure, the Poisson's ratio and Young’s modulus can be improved by adding the tip re-en...
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Article
Open AccessBiomechanical and clinical research of Isobar semi-rigid stabilization devices for lumbar degenerative diseases: a systematic review
While lumbar spinal fusion using rigid rods is a prevalent surgical technique, it can lead to complications such as adjacent segment disease (ASDis). Dynamic stabilization devices serve to maintain physiologic...
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Article
Open AccessDiscovery of the major 15–30 nt mammalian small RNAs, their biogenesis and function
Small RNAs (sRNAs) within 15-30 nt such as miRNA, tsRNA, srRNA with 3’-OH have been identified. However, whether these sRNAs are the major 15-30 nt sRNAs is still unknown. Here we show about 90% mammalian sRNA...
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Article
Open AccessElevated blood and cerebrospinal fluid biomarkers of microglial activation and blood‒brain barrier disruption in anti-NMDA receptor encephalitis
Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune disease characterized by complex neuropsychiatric syndrome and cerebrospinal fluid (CSF) NMDAR antibodies. Triggering receptor expressed on myeloid cell...
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Article
AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis
Cell migration and invasion are two important steps for tumour metastasis, and involved the behaviors including metabolism remodeling and anti-apoptosis. However, it’s still elusive that cancer cells how to an...
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Article
Open AccessAnalysis of the efficacy and risk factors of surgical treatment of recurrent UPJO in adults
To compare the efficacy of secondary pyeloplasty and balloon dilation and to analyze the risk factors for secondary surgical failure in patients with recurrent uretero-pelvic junction obstruction (UPJO).
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Article
Open AccessEther phospholipids are required for mitochondrial reactive oxygen species homeostasis
Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions of mitochondrial metabolism to tumo...
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Article
Open AccessA pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance
Disk-like domain receptor 1 (DDR1) is a crucial regulator of pro-inflammatory mediators and matrix-degrading enzymes. Although mounting evidence supports a vital role for DDR1 in the tumorigenesis of some canc...
