7 Result(s)
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Nicola J. Stonehouse
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Open AccessPublisher Correction: A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation
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Open AccessA conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation
Strategies to prevent the recurrence of poliovirus (PV) after eradication may utilise non-infectious, recombinant virus-like particle (VLP) vaccines. Despite clear advantages over inactivated or attenuated vir...
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Open AccessHigher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for genome replication
Replication of many positive-sense RNA viruses occurs within intracellular membrane-associated compartments. These are thought to provide a favourable environment for replication to occur, concentrating essent...
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Open AccessStructural insight into Pichia pastoris fatty acid synthase
Type I fatty acid synthases (FASs) are critical metabolic enzymes which are common targets for bioengineering in the production of biofuels and other products. Serendipitously, we identified FAS as a contamina...
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Open AccessProduction and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates
The lack of a universal influenza vaccine is a global health problem. Interest is now focused on structurally conserved protein domains capable of eliciting protection against a broad range of influenza virus ...
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Open AccessEvaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research
Chikungunya virus (CHIKV) is becoming an increasing global health issue which has spread across the globe and as far north as southern Europe. There is currently no vaccine or anti-viral treatment available. A...
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Open AccessYIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins
E5 proteins are amongst the least understood of the Human Papillomavirus (HPV) encoded gene products. They are small, membrane-integrated proteins known to modulate a number of critical host pathways associate...
