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Article
Open AccessComparative modelling by restraint-based conformational sampling
Although comparative modelling is routinely used to produce three-dimensional models of proteins, very few automated approaches are formulated in a way that allows inclusion of restraints derived from experime...
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Protocol
Complementary Sources of Protein Functional Information: The Far Side of GO
The GO captures many aspects of functional annotations, but there are other alternative complementary sources of protein function information. For example, enzyme functional annotations are described in a rang...
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Article
Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
In the version of this article initially published, the URL listed for TubercuList was incorrect. The correct URL is https://mycobrowser.epfl.ch/. The error has been corrected in the HTML and PDF versions of t...
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Article
Open AccessUnderstanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
Genomic studies of Mycobacterium tuberculosis bacteria have revealed loci associated with resistance to anti-tuberculosis drugs. However, the molecular consequences of polymorphism within these candidate loci rem...
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Article
Open AccessPrediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches
Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene rpoB. Previously we have hig...
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Article
Open AccessFragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni
Schistosomiasis is caused by parasites of the genus Schistosoma, which infect more than 200 million people. Praziquantel (PZQ) has been the main drug for controlling schistosomiasis for over four decades, but des...
