3 Result(s)
within
Nicholas Furnham
English
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessFragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni
Schistosomiasis is caused by parasites of the genus Schistosoma, which infect more than 200 million people. Praziquantel (PZQ) has been the main drug for controlling schistosomiasis for over four decades, but des...
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Article
Open AccessPrediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches
Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene rpoB. Previously we have hig...
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Article
Open AccessUnderstanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
Genomic studies of Mycobacterium tuberculosis bacteria have revealed loci associated with resistance to anti-tuberculosis drugs. However, the molecular consequences of polymorphism within these candidate loci rem...
