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Article
Open AccessCorrection: Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
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Protocol
Prime Editing for the Installation and Correction of Mutations Causing Inherited Retinal Disease: A Brief Methodology
Inherited retinal diseases ( ) encompass a large heterogeneous group of rare blinding disorders whose etiology originates from in the 280 genes identified to date. Clustered regularly interspaced short palin...
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Chapter and Conference Paper
Rod Photoreceptor-Specific Ablation of Metformin Target, AMPK, in a Preclinical Model of Autosomal Recessive Retinitis Pigmentosa
have shown tremendous progress in the past decade, but the sheer number of disease-causing makes their applicability challenging. In this study we test our hypothesis that retinitis pigmentosa-associated re...
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Article
Open AccessRenormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
Retinitis pigmentosa is characterized by a dysregulation within the metabolic coupling of the retina, particularly between the glycolytic photoreceptors and the oxidative retina pigment epithelium. This phenom...