5 Result(s)
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Nicholas C. Cullen
Neurosciences
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Article
Open AccessNFL is a marker of treatment response in children with SMA treated with nusinersen
Recently, the anti-sense oligonucleotide drug nusinersen was approved for spinal muscular atrophy (SMA) and our aim was to find a response marker for this treatment.
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Article
Open AccessNovel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease
Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as...
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Article
Open AccessThe intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer’s disease
Synaptic degeneration and neuronal loss are early events in Alzheimer’s disease (AD), occurring long before symptom onset, thus making synaptic biomarkers relevant for enabling early diagnosis. The postsynapti...
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Article
Open AccessCerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology
Neurogranin (Ng) is a post-synaptic protein that previously has been shown to be a biomarker for synaptic function when measured in cerebrospinal fluid (CSF). The CSF concentration of Ng is increased in Alzhei...
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Protocol
Convolutional Neural Networks for Rapid and Simultaneous Brain Extraction and Tissue Segmentation
Convolutional neural networks are poised to become a standard technology in neuroimage analysis. This general purpose framework learns both low-level and high-level features directly from images, making them i...
