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  1. Article

    Open Access

    Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease

    Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflam...

    Ghazaleh Eskandari-Sedighi, Leonardo M. Cortez, **g Yang in Molecular Neurobiology (2021)

  2. Article

    Open Access

    Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus

    The Shadoo protein (Sho) exhibits homology to the hydrophobic region of the cellular isoform of prion protein (PrPC). As prion-infected brains gradually accumulate infectivity-associated isoforms of prion protein...

    Sang-Gyun Kang, Charles E. Mays, Nathalie Daude, **g Yang in Molecular Neurobiology (2019)