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Open AccessUtility of ultra-sensitive qPCR to detect Plasmodium falciparum and Plasmodium vivax infections under different transmission intensities
The use of molecular diagnostics has revealed an unexpectedly large number of asymptomatic low-density malaria infections in many malaria endemic areas. This study compared the gains in parasite prevalence obt...
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Open AccessMolecular methods for tracking residual Plasmodium falciparum transmission in a close-to-elimination setting in Zanzibar
Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of r...
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Open AccessAuthor Correction: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessThe temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and...
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Open AccessLongitudinal tracking and quantification of individual Plasmodium falciparum clones in complex infections
Longitudinal tracking of individual Plasmodium falciparum strains in multi-clonal infections is essential for investigating infection dynamics of malaria. The traditional genoty** techniques did not permit trac...
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Open AccessPlasmodium vivax and Plasmodium falciparum infection dynamics: re-infections, recrudescences and relapses
In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genoty** samples from longitudinal cohort studies for merozoite sur...
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Open AccessDevelopment of amplicon deep sequencing markers and data analysis pipeline for genoty** multi-clonal malaria infections
Amplicon deep sequencing permits sensitive detection of minority clones and improves discriminatory power for genoty** multi-clone Plasmodium falciparum infections. New amplicon sequencing and data analysis pro...
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Open AccessSensitive and accurate quantification of human malaria parasites using droplet digital PCR (ddPCR)
Accurate quantification of parasite density in the human host is essential for understanding the biology and pathology of malaria. Semi-quantitative molecular methods are widely applied, but the need for an ex...
