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Efficacy and safety exposure–response analyses of entrectinib in patients with advanced or metastatic solid tumors

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  1. Article

    Open Access

    Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations

    Entrectinib is a central nervous system-active potent inhibitor of tropomyosin receptor kinase (TRK), with anti-tumor activity against neurotrophic NTRK gene fusion-positive tumors. This study investigates the ph...

    Georgina Meneses-Lorente, Elena Guerini… in Cancer Chemotherapy and Pharmacology (2023)

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  2. Article

    Open Access

    In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK)

    Background Entrectinib is a CNS-active, potent inhibitor of tyrosine receptor kinases A/B/C, ROS1 and anaplastic lymphoma kinase approved for use in patients with solid tumors. We describe the in vitro and clinic...

    Georgina Meneses-Lorente, Stephen Fowler, Elena Guerini… in Investigational New Drugs (2022)

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  3. Article

    Open Access

    Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors

    Background: Entrectinib is an oral, CNS-active, potent inhibitor of tyrosine receptor kinases A/B/C, tyrosine kinase ROS proto-oncogene 1, and anaplastic lymphoma kinase approved for use in patients with solid tu...

    Georgina Meneses-Lorente, Darren Bentley, Elena Guerini… in Investigational New Drugs (2021)

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