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  1. Article

    Open Access

    Expression of AKR1C3 and CNN3 as markers for detection of lymph node metastases in colorectal cancer

    The aim of the study was to identify a set of discriminating genes that could be used for the prediction of Lymph node (LN) metastasis in human colorectal cancer (CRC), and for this, we compared the whole gen...

    Chiaki Nakarai, Kayo Osawa, Minami Akiyama… in Clinical and Experimental Medicine (2015)

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  2. No Access

    Article

    Augumentation of splenic antitumor immunity by local immunotherapy in gastric cancer patients

    We previously reported that the antitumor effect of OK-432, a streptococcal preparation, was markedly augmented when this agent was injected into tumors together with fibrinogen. In order to elucidate the effe...

    Taro Wakasugi M.D., Tsutomu Takeda, Takushi Monden, Yoshihiro Katsumoto… in Biotherapy (1997)

  3. No Access

    Article

    Augmentation of antitumor immunity in regional lymph nodes by local immunotherapy

    We have previously reported that the antitumor effect of OK-432, a streptococcal preparation, is markedly augmented when injected intratumorally together with fibrinogen (OK-432/fbg) [1]. In order to elucidate...

    Isao Sakita, Takushi Monden, Hirohito Nagaoka, Yoshihiro Katsumoto… in Biotherapy (1993)

  4. No Access

    Article

    The effect of local immunotherapy for breast cancer using a mixture of OK-432 and fibrinogen supplemented with activated macrophages

    OK-432 is an immunomodulatory agent prepared from a strain ofStreptococcus pyogenes. We have previously reported that intratumoral injection of a mixture of OK-432 and fibrinogen (hereinafter referred to as OK/fb...

    Tsutomu Takeda, Tetsuro Kobayashi, Takushi Monden, Yoshihiro Katsumoto… in Biotherapy (1993)

  5. No Access

    Article

    Establishment of cytotoxic CD4+ T cell clones from cancer patients treated by local immunotherapy

    We have previously reported that the antitumor effect of OK-432, aStreptococcal preparation, is markedly augmented when injected intratumorally together with fibrinogen (Cancer, 69: 636–642, 1992). In order to el...

    Hirohito Nagaoka M.D., Takushi Monden, Isao Sakita, Yoshihiro Katsumoto… in Biotherapy (1992)