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  1. Article

    Open Access

    Structural insights into the HBV receptor and bile acid transporter NTCP

    Around 250 million people are infected with hepatitis B virus (HBV) worldwide1, and 15 million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater risk of severe liver disease2....

    Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son… in Nature (2022)

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  2. Article

    Open Access

    Structural basis of CXC chemokine receptor 1 ligand binding and activation

    Neutrophil granulocytes play key roles in innate immunity and sha** adaptive immune responses. They are attracted by chemokines to sites of infection and tissue damage, where they kill and phagocytose bacter...

    Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri… in Nature Communications (2023)

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  3. Article

    Open Access

    Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2

    Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which are associated with lipolytic and a...

    Jae-Hyun Park, Kouki Kawakami, Naito Ishimoto, Tatsuya Ikuta… in Nature Communications (2023)

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  4. No Access

    Article

    Structural basis of hepatitis B virus receptor binding

    Hepatitis B virus (HBV), a leading cause of develo** hepatocellular carcinoma affecting more than 290 million people worldwide, is an enveloped DNA virus specifically infecting hepatocytes. Myristoylated pre...

    **ta Asami, Jae-Hyun Park, Yayoi Nomura… in Nature Structural & Molecular Biology (2024)