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  1. Article

    Open Access

    Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2

    Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which are associated with lipolytic and a...

    Jae-Hyun Park, Kouki Kawakami, Naito Ishimoto, Tatsuya Ikuta in Nature Communications (2023)

  2. Article

    Open Access

    Structural basis of CXC chemokine receptor 1 ligand binding and activation

    Neutrophil granulocytes play key roles in innate immunity and sha** adaptive immune responses. They are attracted by chemokines to sites of infection and tissue damage, where they kill and phagocytose bacter...

    Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri in Nature Communications (2023)

  3. Article

    Open Access

    Structural insights into the HBV receptor and bile acid transporter NTCP

    Around 250 million people are infected with hepatitis B virus (HBV) worldwide1, and 15 million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater risk of severe liver disease2....

    Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son in Nature (2022)