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Combinatorial strategies to target RAS-driven cancers

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  1. Article

    Open Access

    An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

    KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by K...

    Adrian Vallejo, Naiara Perurena, Elisabet Guruceaga… in Nature Communications (2017)

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  2. Article

    Open Access

    EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth

    Activated protein C/endothelial protein C receptor (APC/EPCR) axis is physiologically involved in anticoagulant and cytoprotective activities in endothelial cells. Emerging evidence indicates that EPCR also pl...

    Naiara Perurena, Carolina Zandueta… in Journal of Hematology & Oncology (2017)

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