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  1. Article

    Open Access

    Combined administration of laminin-221 and prostacyclin agonist enhances endogenous cardiac repair in an acute infarct rat heart

    Although endogenous cardiac repair by recruitment of stem cells may serve as a therapeutic approach to healing a damaged heart, how to effectively enhance the migration of stem cells to the damaged heart is un...

    Nagako Sougawa, Shigeru Miyagawa, Takuji Kawamura, Ryohei Matsuura… in Scientific Reports (2021)

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  2. Article

    Open Access

    Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application

    Transplantation of cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSC-CMs) is a promising treatment for heart failure, but residual undifferentiated hiPSCs and malignant transformed ...

    Emiko Ito, Shigeru Miyagawa, Maki Takeda, Ai Kawamura, Akima Harada… in Scientific Reports (2019)

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  3. Article

    Open Access

    Immunologic targeting of CD30 eliminates tumourigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy

    Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graf...

    Nagako Sougawa, Shigeru Miyagawa, Satsuki Fukushima, Ai Kawamura… in Scientific Reports (2018)

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