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Article
Open AccessAn open-source, automated, and cost-effective platform for COVID-19 diagnosis and rapid portable genomic surveillance using nanopore sequencing
The COVID-19 pandemic, caused by SARS-CoV-2, has emphasized the necessity for scalable diagnostic workflows using locally produced reagents and basic laboratory equipment with minimal dependence on global supp...
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Article
Open AccessDNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages
Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. H...
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Article
Open AccessImpact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity
The excessive inflammatory responses provoked by SARS-CoV-2 infection are critical factors affecting the severity and mortality of COVID-19. Previous work found that two adjacent co-occurring mutations R203K a...
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Article
Open AccessVolumetric thermo-convective casson fluid flow over a nonlinear inclined extended surface
The thermophysical features of Casson fluid flow caused by a nonlinear permeable stretchable surface are assessed in the present study. The computational model of Casson fluid is used to define viscoelasticity...
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Article
Open AccessSARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load
Monitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes collected from patients in Saudi Arabia from March...
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Article
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for rapid and sensitive protein detection and quantification in simple and robust formats for widespread point-of-care applications. He...
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Article
Open AccessNumerical approach towards gyrotactic microorganisms hybrid nanoliquid flow with the hall current and magnetic field over a spinning disk
The article explores the effect of Hall current, thermal radiation, and magnetic field on hybrid nanofluid flow over the surface of a spinning disk. The motive of the present effort is to upgrade the heat tran...
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Article
Human coronaviruses with emphasis on the COVID-19 outbreak
Human coronaviruses are known as respiratory pathogens mainly associated with a range of respiratory diseases. In the past 18 years, the beginning of severe acute respiratory syndrome human coronavirus (SARS-H...
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Article
Open AccessUbiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cells
While the role of Polycomb group protein-mediated “cell memory” is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells. Emergin...
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Article
Open AccessPharmacological profile of the aerial parts of Rubus ulmifolius Schott
As aerial parts of Rubus ulmifolius contains phytochemicals like flavonoids and tannins. And whereas flavonoids and tannins have antioxidant and antipyretic activity, hence, current work is carried out to screen ...
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Article
Open AccessWealth inequality and utilization of reproductive health services in the Republic of Vanuatu: insights from the multiple indicator cluster survey, 2007
Although the Republic of Vanuatu has improved maternal indicators, more needs to be done to improve equity among the poorest in the use of reproductive health services to expedite the progress towards the Mill...
