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  1. Article

    Open Access

    Dicentric chromosome assay using a deep learning-based automated system

    The dicentric chromosome assay is the “gold standard” in biodosimetry for estimating radiation exposure. However, its large-scale deployment is limited owing to its time-consuming nature and requirement for ex...

    Soo Kyung Jeong, Su Jung Oh, Song-Hyun Kim, Seungsoo Jang in Scientific Reports (2022)

  2. Article

    Open Access

    Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells

    UHRF1 (ubiquitin-like, with PHD and RING finger domains 1) plays a crucial role in DNA methylation, chromatin remodeling and gene expression and is aberrantly upregulated in various types of human cancers. How...

    Ji-Hyun Kim, Jae-Woong Shim, Da-Young Eum, Sung Dae Kim, Si Ho Choi in Scientific Reports (2017)

  3. Article

    Open Access

    NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation

    Oxygen and glucose deprivation (OGD) due to insufficient blood circulation can decrease cancer cell survival and proliferation in solid tumors. OGD increases the intracellular [AMP]/[ATP] ratio, thereby activa...

    Hyemi Lee, Eun-Taex Oh, Bo-Hwa Choi, Moon-Taek Park, Ja-Kyeong Lee in Scientific Reports (2015)