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Article
Open AccessDicentric chromosome assay using a deep learning-based automated system
The dicentric chromosome assay is the “gold standard” in biodosimetry for estimating radiation exposure. However, its large-scale deployment is limited owing to its time-consuming nature and requirement for ex...
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Article
Open AccessDownregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells
UHRF1 (ubiquitin-like, with PHD and RING finger domains 1) plays a crucial role in DNA methylation, chromatin remodeling and gene expression and is aberrantly upregulated in various types of human cancers. How...
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Article
Open AccessNQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation
Oxygen and glucose deprivation (OGD) due to insufficient blood circulation can decrease cancer cell survival and proliferation in solid tumors. OGD increases the intracellular [AMP]/[ATP] ratio, thereby activa...