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  1. No Access

    Article

    Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells

    Histone deacetylase (HDAC) plays an important role in cancer onset and progression. Therefore, inhibition of HDAC offers potential as an effective cancer treatment regimen. CG200745, (E)-N1-(3-(dimethylamino)prop...

    Eun-Taex Oh, Moon-Taek Park, Bo-Hwa Choi, Seonggu Ro… in Investigational New Drugs (2012)

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    Article

    Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways

    It has been well known that Ras signaling is involved in various cellular processes, including proliferation, differentiation, and apoptosis. However, distinct cellular functions of Ras isozymes are not fully ...

    Jung-A Choi, Moon-Taek Park, Chang-Mo Kang, Hong-Duck Um, Sangwoo Bae… in Oncogene (2004)

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    Article

    Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells

    We have previously reported that ursolic acid, a pentacyclic triterpene acid, inhibited the invasion of HT1080 human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9. Since the chemi...

    Hee-Jae Cha, Moon-Taek Park, Hae-Young Chung, Nam Deuk Kim, Hiroshi Sato… in Oncogene (1998)