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within Momoko Ohori Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

    The molecular mechanism responsible that determines cell fate after mitotic slippage is unclear. Here we investigate the post-mitotic effects of different mitotic aberrations—misaligned chromosomes produced by...

    Akihiro Ohashi, Momoko Ohori, Kenichi Iwai, Yusuke Nakayama… in Nature Communications (2015)

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  2. Article

    Open Access

    CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

    CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, ...

    Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki… in Nature Communications (2017)

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  3. Article

    Open Access

    Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

    Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that converts cholesterol into 24S-hydroxycholesterol, the primary mechanism of cholesterol catabolism in the brain. The therapeutic potential of CH24...

    Toshiya Nishi, Shinichi Kondo, Maki Miyamoto, Sayuri Watanabe… in Scientific Reports (2020)

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