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    Chapter

    Translin/TRAX Deficiency Affects Mesenchymal Differentiation Programs and Induces Bone Marrow Failure

    The decision regarding self-renewal versus differentiation of hematopoietic stem cells (HSCs) is a crucial issue in bone marrow hematopoiesis. We have generated mice homozygous for an inactivating mutation of ...

    Reiko Ishida, Katsunori Aoki, Kazuhiko Nakahara… in Stem Cells and Human Diseases (2012)

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    Article

    Polygenic architecture informs potential vulnerability to drug-induced liver injury

    Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. ...

    Masaru Koido, Eri Kawakami, Junko Fukumura, Yui Noguchi, Momoko Ohori… in Nature Medicine (2020)