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  1. Article

    Open Access

    PITX2C increases the stemness features of hepatocellular carcinoma cells by up-regulating key developmental factors in liver progenitor

    Tumor cells exhibited phenotypic and molecular characteristics similar to their lineage progenitor cells. Liver developmental signaling pathways are showed to be associated with HCC development and oncogenesis...

    Lingxi Jiang, **a Wang, Fangfang Ma… in Journal of Experimental & Clinical Cancer … (2022)

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  2. Article

    Open Access

    TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells

    Ten-eleven translocation 1 (TET1) is a dioxygenase that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) to induce DNA demethylation. TET1 has been reported to be absent in cancers, and to i...

    Jian Wu, Hongzhe Li, Minmin Shi, Youwei Zhu… in Journal of Experimental & Clinical Cancer … (2019)

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  3. Article

    Open Access

    The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation

    The aim of this study is to explore the molecular mechanism of the LIM protein Ajuba and the transcription factor SP1 in the pathogenesis and progression of PDAC. Ajuba is a newly defined transcriptional co-re...

    Bosen Zhang, Liwei Song, Jiali Cai, Lei Li… in Journal of Experimental & Clinical Cancer … (2019)

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