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  1. Article

    Open Access

    Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives

    Interleukin-15 (IL-15) is a critical cytokine for the development, proliferation, and function of natural killer (NK) cells, NKT cells, and CD8+ memory T cells and has become one of the most promising protein mol...

    Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, **g Wu, Yin Yu… in Microbial Cell Factories (2021)

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  2. Article

    Open Access

    Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-α/Fc fusion proteins expressed in Pichia pastoris

    Interferon (IFN)-α has been commonly used as an antiviral drug worldwide; however, its short half-life in circulation due to its low molecular weight and sensitivity to proteases impacts its efficacy and patie...

    Hao Jia, Yugang Guo, ** Song, Changsheng Shao, **g Wu… in Microbial Cell Factories (2016)

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