68 Result(s)
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Ming-Yan **ng
Life Sciences
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Article
Open AccessUnraveling the efficacy of verbascoside in thwarting MRSA pathogenicity by targeting sortase A
In the fight against hospital-acquired infections, the challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) necessitates the development of novel treatment methods. This study focused on undermin...
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Open AccessGraphKM: machine and deep learning for KM prediction of wildtype and mutant enzymes
Michaelis constant (KM) is one of essential parameters for enzymes kinetics in the fields of protein engineering, enzyme engineering, and synthetic biology. As overwhelming experimental measurements of KM are dif...
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Open AccessRetraction Note: Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7
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Boric Acid Inhibits RANKL-Stimulated Osteoclastogenesis In Vitro and Attenuates LPS-Induced Bone Loss In Vivo
Boron and boric acid (BA) can promote osteogenic differentiation and reduce bone resorption, which controls bone growth and maintenance of bone tissue. It has been reported that BA activates PERK-eIF2α signali...
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Increasing soil heterogeneity strengthens the inhibition of a native woody plant by an invasive congener
Environmental heterogeneity can influence biological invasions by altering the interspecific competition between native and invasive species. Soils are a key component of the abiotic environment that can vary ...
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Open AccessA co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ
Berberine (BBR) exerts specific therapeutic effects on various diseases such as diabetes, obesity, and other inflammation-associated diseases. However, the low oral bioavailability (below 1%) of berberine due ...
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Comparison between the exotic Coreopsis grandiflora and native Dendranthema indicum across variable nitrogen deposition conditions
Functional trait values and phenotypic plasticity are the two main factors associated with the invasiveness of exotic plants. In this study, we aimed to determine the effects of plant functional traits and phe...
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High expression of HOXB3 predicts poor prognosis and correlates with tumor immunity in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is one of the most prevalent human cancers worldwide. The homeobox-B (HOXB) gene cluster has been reported to contribute to cancer development. Nevertheless, the expression status, c...
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Open AccessDifferential microRNA expression, microRNA arm switching, and microRNA:long noncoding RNA interaction in response to salinity stress in soybean
Soybean is a major legume crop with high nutritional and environmental values suitable for sustainable agriculture. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are ...
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Open AccessA small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a deadly and highly prevalent malignancy. Targeting activated-EGFR mutations in NSCLC via EGFR tyrosine kinase inhibitor (EGFR-TKI) initially achieves a profound therapeut...
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Joint protection strategies for Saccharomyces boulardii: exogenous encapsulation and endogenous biofilm structure
Biofilms are heterogeneous structures composed of microorganisms and the surrounding extracellular polymeric substances (EPS) that protect the microbial cells from harsh environments. Saccharomyces boulardii i...
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Multi-generational effects of simulated herbivory and habitat types on the invasive weed Alternanthera philoxeroides: implications for biological control
Long-term pre-release evaluations of how invasive plants respond to herbivory in introduced ranges can help identify the most effective biological control agents. However, most evaluations have been conducted ...
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Open AccessTargeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma
The histone methyltransferase EZH2 silences gene expression via H3 lysine 27 trimethylation and has been recognized as an important antitumour therapeutic target. However, the clinical application of existing ...
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Open AccessTHAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the progression of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in the digestive system with a high incidence and poor prognosis. Long non-coding RNAs (LncRNA) have been reported to be clo...
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Tree mortality and biomass loss in drought-affected forests of East Texas, USA
Changes in tree mortality due to severe drought can alter forest structure, composition, dynamics, ecosystem services, carbon fluxes, and energy interactions between the atmosphere and land surfaces. We utiliz...
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Open AccessPredicting the potential distribution of the parasitic Cuscuta chinensis under global warming
The climate is the dominant factor that affects the distribution of plants. Cuscuta chinensis is a stem holoparasitic plant without leaves or roots, which develops a haustorium and sucks nutrients from host plant...
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Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG)
neuECG, the simultaneous noninvasive recording of ECG and skin sympathetic nerve activity (SKNA), directly records sympathetic nerve activity over a long period of time. It can be used to measure sympathetic t...
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Open AccessIncreased soil moisture aggravated the competitive effects of the invasive tree Rhus typhina on the native tree Cotinus coggygria
Invasive exotic species have caused significant problems, and the effects of extreme precipitation and drought, which might occur more frequently under the global climate change scenarios, on interspecific rel...
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Transcriptome analysis of the dimorphic transition induced by pH change and lipid biosynthesis in Trichosporon cutaneum
Trichosporon cutaneum, a dimorphic oleaginous yeast, has immense biotechnological potential, which can use lignocellulose hydrolysates to accumulate lipids. Our preliminary studies on its dimorphic transition sug...
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Water-saving and drought-resistance rice: from the concept to practice and theory
The resource and environmental challenges faced by rice production call for resource-saving and environment-friendly rice varieties. Water-saving and drought-resistance rice (WDR) is a new type of cultivated r...
