58 Result(s)

Article

Targeted phasing of 2–200 kilobase DNA fragments with a short-read sequencer and a single-tube linked-read library method

In the human genome, heterozygous sites refer to genomic positions with a different allele or nucleotide variant on the maternal and paternal chromosomes. Resolving these allelic differences by chromosomal cop...

Veronika Mikhaylova, Madison Rzepka, Tetsuya Kawamura, Yu **a… in Scientific Reports (2024)

Article

Publisher Correction: High resolution optical map** of cardiac electrophysiology in pre-clinical models

Christopher O’Shea, James Winter, S. Nashitha Kabir, Molly O’Reilly… in Scientific Data (2024)

Article

Stress–strain characteristics of FRP–PVC confined spontaneous combustion gangue concrete columns

A total of 40 fiber reinforced polymer (FRP) and polyvinyl chloride (PVC) confined spontaneous combustion gangue coarse-aggregate concrete (SAC) specimens were subjected to axial compression tests and theoreti...

**yang Zhang, Haiqing Liu, **li Wang, Ming Lei, Zimu Chen in Scientific Reports (2024)

Article

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Gankyrin is found in high levels in triple-negative breast cancer (TNBC) and has been established to form a complex with the E3 ubiquitin ligase MDM2 and p53, resulting in the degradation of p53 in hepatocarci...

Ming Lei, Yun-Long Zhang, Feng-Ying Huang, Heng-Yu Chen… in Scientific Reports (2023)

Article

Dbh⁺ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function. Yet the biological and physiological ide...

Tianyi Sun, Alexander Grassam-Rowe, Zhaoli Pu, Yangpeng Li… in Nature Communications (2023)

Article

C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy

The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains ...

Shen Zhang, Mindan Tong, Denghao Zheng, Huiying Huang, Linsen Li… in Nature Communications (2023)

Article

Integration of 3D-printed cerebral cortical tissue into an ex vivo lesioned brain slice

Engineering human tissue with diverse cell types and architectures remains challenging. The cerebral cortex, which has a layered cellular architecture composed of layer-specific neurons organised into vertical...

Yongcheng **, Ellina Mikhailova, Ming Lei, Sally A. Cowley… in Nature Communications (2023)

Article

Single-cell RNA sequencing of murine hearts for studying the development of the cardiac conduction system

The development of the cardiac conduction system (CCS) is essential for correct heart function. However, critical details on the cell types populating the CCS in the mammalian heart during the development rema...

Huiying Ren, **aolin Zhou, Jun Yang, Kun Kou, Tangting Chen, Zhaoli Pu… in Scientific Data (2023)

Article

Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train

Intraflagellar transport (IFT) trains, the polymers composed of two multi-subunit complexes, IFT-A and IFT-B, carry out bidirectional intracellular transport in cilia, vital for cilia biogenesis and signaling....

Yuanyuan Ma, Jun He, Shaobai Li, Deqiang Yao, Chenhui Huang… in Nature Communications (2023)

Article

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants

EDA is a tumor necrosis factor (TNF) family member, which functions together with its cognate receptor EDAR during ectodermal organ development. Mutations of EDA have long been known to cause X‐linked hypohidroti...

Kang Yu, Chenhui Huang, Futang Wan, Cailing Jiang, Juan Chen… in Nature Communications (2023)

Article

Interface slip of steel–concrete composite beams reinforced with CFRP sheet under creep effect

Under the creep action of composite steel and concrete beams reinforced by carbon-fiber-reinforced polymer (CFRP) sheet, the face of the CFRP sheet, steel beam, and concrete slab beam produce relative slip. Th...

**angyang Jian, Ni Zhang, Haiqing Liu, Zhongwei Zhao, Ming Lei… in Scientific Reports (2022)

Article

Low-cost synthesis of small molecule acceptors makes polymer solar cells commercially viable

The acceptor-donor-acceptor (A–D–A) or A–DA’D–A structured small molecule acceptors (SMAs) have triggered substantial progress for polymer solar cells (PSCs). However, the high−cost of the SMAs impedes the com...

Hongyuan Fu, Jia Yao, Ming Zhang, Lingwei Xue, Qiuju Zhou… in Nature Communications (2022)

Article

Transition-metal-free synthesis of pyrimidines from lignin β-O-4 segments via a one-pot multi-component reaction

Heteroatom-participated lignin depolymerization for heterocyclic aromatic compounds production is of great importance to expanding the product portfolio and meeting value-added biorefinery demand, but it is al...

Bo Zhang, Tenglong Guo, Zhewei Li, Fritz E. Kühn, Ming Lei… in Nature Communications (2022)

Article

High resolution optical map** of cardiac electrophysiology in pre-clinical models

Optical map** of animal models is a widely used technique in pre-clinical cardiac research. It has several advantages over other methods, including higher spatial resolution, contactless recording and direct...

Christopher O’Shea, James Winter, S. Nashitha Kabir, Molly O’Reilly… in Scientific Data (2022)

Article

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer

Standard first-line chemotherapy results in disease progression and death within one year in most patients with human epidermal growth factor receptor 2 (HER2)-negative gastro-oesophageal adenocarcinoma^1–4. Nivol...

Kohei Shitara, Jaffer A. Ajani, Markus Moehler, Marcelo Garrido, Carlos Gallardo… in Nature (2022)

Article

A dataset of dual calcium and voltage optical map** in healthy and hypertrophied murine hearts

Pathological hypertrophy underlies sudden cardiac death due to its high incidence of occurrence of ventricular arrhythmias. The alteration of transmural electrophysiological properties in hypertrophic cardiac ...

Shicheng He, Kun Kou, Christopher O’Shea, Tangting Chen, Razik Mu-u-min… in Scientific Data (2021)

Article

The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3

As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation remodeling via Lands’ cycle. The re-acylati...

Qing Zhang, Deqiang Yao, Bing Rao, Liyan Jian, Yang Chen, Kexin Hu… in Nature Communications (2021)

Article

Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment

During meiosis, chromosomes exhibit dramatic changes in morphology and intranuclear positioning. How these changes influence homolog pairing, alignment, and recombination remain elusive. Using Hi-C, we systema...

Wu Zuo, Guangming Chen, Zhimei Gao, Shuai Li, Yanyan Chen… in Nature Communications (2021)

Article

The SUN1-SPDYA interaction plays an essential role in meiosis prophase I

Chromosomes pair and synapse with their homologous partners to segregate correctly at the first meiotic division. Association of telomeres with the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex comp...

Yanyan Chen, Yan Wang, Juan Chen, Wu Zuo, Yong Fan, Sijia Huang… in Nature Communications (2021)

Article

Orthogonal photochemistry-assisted printing of 3D tough and stretchable conductive hydrogels

3D-printing tough conductive hydrogels (TCHs) with complex structures is still a challenging task in related fields due to their inherent contrasting multinetworks, uncontrollable and slow polymerization of co...

Hongqiu Wei, Ming Lei, ** Zhang, **song Leng, Zijian Zheng… in Nature Communications (2021)