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  1. No Access

    Article

    Amyloid-β metabolism in Niemann-Pick C disease models and patients

    Niemann-Pick type C (NPC) is a progressive neurodegenerative lysosomal disease with altered cellular lipid trafficking. The metabolism of amyloid-β (Aβ) - previously mainly studied in Alzheimer’s disease - has...

    Niklas Mattsson, Maria Olsson, Mikael K. Gustavsson… in Metabolic Brain Disease (2012)

  2. No Access

    Article

    Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

    A proposed key event in the pathogenesis of Alzheimer’s disease (AD) is the formation of neurotoxic amyloid β (Aβ) oligomers and amyloid plaques in specific brain regions that are affected by the disease. The ...

    Erik Portelius, Nenad Bogdanovic, Mikael K. Gustavsson… in Acta Neuropathologica (2010)

  3. Article

    Open Access

    A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease

    LY450139 (semagacestat) inhibits γ-secretase, a key enzyme for generation of amyloid β (Aβ), the peptide deposited in plaques in Alzheimer disease (AD). Previous data have shown that LY450139 lowers plasma Aβ,...

    Erik Portelius, Robert A Dean, Mikael K Gustavsson… in Alzheimer's Research & Therapy (2010)

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  4. Article

    Open Access

    Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1A431E-associated familial Alzheimer's disease

    Alzheimer's disease (AD) is associated with deposition of amyloid β (Aβ) in the brain, which is reflected by low concentration of the Aβ1-42 peptide in the cerebrospinal fluid (CSF). There are at least 15 addi...

    Erik Portelius, Ulf Andreasson, John M Ringman… in Molecular Neurodegeneration (2010)

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