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Article

A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease

LY450139 (semagacestat) inhibits γ-secretase, a key enzyme for generation of amyloid β (Aβ), the peptide deposited in plaques in Alzheimer disease (AD). Previous data have shown that LY450139 lowers plasma Aβ,...

Erik Portelius, Robert A Dean, Mikael K Gustavsson… in Alzheimer's Research & Therapy (2010)