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  1. Article

    Open Access

    AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2

    The L-type Ca2+ channel CaV1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca2+ channel via PKA,...

    Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy… in Nature Communications (2020)

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  2. Article

    Open Access

    Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle

    Diabetes affects millions of people worldwide. This devastating disease dramatically increases the risk of develo** cardiovascular disorders. A hallmark metabolic abnormality in diabetes is hyperglycemia, wh...

    Madeline Nieves-Cintrón, Víctor A. Flores-Tamez… in Cellular and Molecular Life Sciences (2021)

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  3. No Access

    Chapter

    Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia

    Diabetes is a leading cause of disability and mortality worldwide. A major underlying factor in diabetes is the excessive glucose levels in the bloodstream (e.g., hyperglycemia). Vascular complications directl...

    Miguel Martín-Aragón Baudel, Junyoung Hong… in Voltage-gated Ca2+ Channels: Pharmacology,… (2023)