10 Result(s)
within
Michael Worobey
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Sexual transmission of HIV in Africa
Other routes of infection are not the dominant contributor to the African epidemic.
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Article
Contaminated polio vaccine theory refuted
Despite strong evidence to the contrary1,2,3,4,5, speculation continues that the AIDS virus, human immunodeficiency virus type 1 (HIV-1), may have crossed into humans as a result of contamination of the oral poli...
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Article
Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960
A histological specimen from the University of Kinshasa archives has been used to obtain HIV gene sequences dating back to the pre-AIDS era. From a lymph node biopsy taken in 1960 from an adult female in Léopo...
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Article
Open AccessOrigins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
A phylogenetic analysis of swine-origin H1N1 influenza A virus provides evidence that the virus is a reassortment possessing genes from avian, swine and human origin viruses. The pandemic virus appears to have...
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Article
A synchronized global sweep of the internal genes of modern avian influenza virus
A local molecular clock approach shows that most genetic diversity in avian influenza virus (AIV) arose in a recent global sweep and that avian strains are the sister group to equine H7N7; most of the 1918 pan...
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Article
1970s and ‘Patient 0’ HIV-1 genomes illuminate early HIV/AIDS history in North America
A study of the early genetic diversity and history of the HIV-1 epidemic in North America through sequencing of eight full-length viral genomes from the 1970s.
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Article
Molecular map** of Zika spread
Evolutionary trees constructed using both newly sequenced and previously available Zika virus genomes reveal how the recent outbreak arose in Brazil and spread across the Americas. See Letters p...
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Article
Open AccessAccommodating individual travel history and unsampled diversity in Bayesian phylogeographic inference of SARS-CoV-2
Spatiotemporal bias in genome sampling can severely confound discrete trait phylogeographic inference. This has impeded our ability to accurately track the spread of SARS-CoV-2, the virus responsible for the C...
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Article
Open AccessArchival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV...
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Article
Open AccessCompetent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination
Aging is associated with a reduced magnitude of primary immune responses to vaccination. mRNA-based SARS-CoV-2 vaccines have shown efficacy in older adults but virus variant escape is still unclear. Here we an...
