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Article
Open AccessAccuracy of patient-specific I-131 dosimetry using hybrid whole-body planar-SPECT/CT I-123 and I-131 imaging
This study aimed to assess the accuracy of patient-specific absorbed dose calculations for tumours and organs at risk in radiopharmaceutical therapy planning, utilizing hybrid planar-SPECT/CT imaging.
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Article
Open Access3D printed non-uniform anthropomorphic phantoms for quantitative SPECT
A 3D printing grid-based method was developed to construct anthropomorphic phantoms with non-uniform activity distributions, to be used for evaluation of quantitative SPECT images. The aims were to characteriz...
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Article
Open AccessFeasibility of 177Lu activity quantification using a small portable CZT-based gamma-camera
In image processing for activity quantification, the end goal is to produce a metric that is independent of the measurement geometry. Photon attenuation needs to be accounted for and can be accomplished utiliz...
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Article
Open AccessOn the use of solid 133Ba sources as surrogate for liquid 131I in SPECT/CT calibration: a European multi-centre evaluation
Commissioning, calibration, and quality control procedures for nuclear medicine imaging systems are typically performed using hollow containers filled with radionuclide solutions. This leads to multiple source...
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Article
Open AccessMachine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio
We developed a method of standardizing the heart-to-mediastinal ratio in 123I-labeled meta-iodobenzylguanidine (MIBG) images using a conversion coefficient derived from a dedicated phantom. This study aimed to cr...
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Article
Open AccessPhase II trial demonstrates the efficacy and safety of individualized, dosimetry-based 177Lu-DOTATATE treatment of NET patients
Radionuclide therapy with 177Lu-DOTATATE is well established for patients with advanced somatostatin receptor–positive neuroendocrine tumors with a standard schedule of 7.4 GBq at four occasions. However, this ap...
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Article
Open AccessMonte Carlo modelling of a compact CZT-based gamma camera with application to 177Lu imaging
Semiconductor gamma-camera systems based on cadmium zinc telluride (CZT) detectors present new challenges due to an energy-response that includes effects of low-energy tailing. In particular, such energy tails...
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Article
Open AccessEvaluation of Iodine-123 and Iodine-131 SPECT activity quantification: a Monte Carlo study
The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative ...
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Article
Open AccessA multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project
Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the r...
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Chapter
Quantitative SPECT Imaging
A scintillation camera is essentially a device that measures two-dimensional (2D) images of a radionuclide distribution in vivo by detecting emitted photons. Due to the construction of the collimator, events i...
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Article
Open AccessFeasibility of simplifying renal dosimetry in 177Lu peptide receptor radionuclide therapy
Recently, 177Lu-dotatate therapy for neuroendocrine tumours has received regulatory approval. Dosimetry can be used to optimize treatment on an individual basis, but there is no international consensus as to how ...
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Article
Open AccessMonte Carlo-based quantitative pinhole SPECT reconstruction using a ray-tracing back-projector
Monte Carlo simulations provide accurate models of nuclear medicine imaging systems as they can properly account for the full physics of photon transport. The accuracy of the model included in the maximum-like...
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Article
Open AccessIndividualised 177Lu-DOTATATE treatment of neuroendocrine tumours based on kidney dosimetry
To present data from an interim analysis of a Phase II trial designed to determine the feasibility, safety, and efficacy of individualising treatment based on renal dosimetry, by giving as many cycles as possi...
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Article
Open AccessEANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision
Since the publication of the European Association of Nuclear Medicine (EANM) procedural guidelines for radionuclide myocardial perfusion imaging (MPI) in 2005, many small and some larger steps of progress have...
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Article
Open AccessEvaluation of inter-departmental variability of ejection fraction and cardiac volumes in myocardial perfusion scintigraphy using simulated data
Myocardial perfusion scintigraphy (MPS) is a clinically useful noninvasive imaging modality for diagnosing patients with suspected coronary artery disease. By utilizing gated MPS, the end diastolic volume (EDV...
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Chapter
Quantitative SPECT Imaging
The scintillation camera is essentially a device that measures 2D images of a radionuclide distribution in vivo by detecting emitted photons. Due to the construction of the collimator, events in the image comi...
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Article
Monte Carlo evaluation of object shape effects in iodine-131 SPET tumor activity quantification
In our clinical iodine-131 single-photon emission tomography (SPET) quantification for radioimmunotherapy, calibration and partial volume correction are based on measurements with phantoms containing spheres ...
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Article
Evaluation of optimally designed planar-concave collimators in single-photon emission tomography
The imaging properties of optimally designed planar-concave (PC) collimators were evaluated by means of Monte Carlo simulations. The evaluation was done with respect to total system spatial resolution and the ...
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Chapter and Conference Paper
Registration of abdominal CT and SPECT images using Compton scatter data
The present study investigates the possibility to utilize Compton scatter data for registration of abdominal SPECT images. A method for registration to CT is presented, based on principal component analysis an...
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Article
Quantitative SPECT by attenuation correction of the projection set using transmission data: evaluation of a method
A method for measuring attenuation coefficients in single-photon emission tomography (SPECT) is described and evaluated, together with a method for attenuation correction using these measured attenuation coeff...
