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Drug Target Elucidation Through Isolation and Analysis of Drug-Resistant Mutants in Cryptococcus neoformans

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  1. Article

    Open Access

    Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

    Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin ...

    Praveen R. Juvvadi, David Fox III, Benjamin G. Bobay… in Nature Communications (2019)

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  2. Article

    Open Access

    Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex

    The unfolded protein response (UPR) pathway, consisting of the evolutionarily conserved Ire1 kinase/endonuclease and the bZIP transcription factor Hxl1, is critical for the pathogenicity of Cryptococcus neoforman...

    Kwang-Woo Jung, Kyung-Tae Lee, Anna F. Averette, Michael J. Hoy… in Scientific Reports (2018)

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