11 Result(s)

Article

Activation of distinct inflammatory pathways in subgroups of LR-MDS

Aberrant innate immune signaling has been identified as a potential key driver of the complex pathophysiology of myelodysplastic neoplasms (MDS). This study of a large, clinically and genetically well-characte...

Marie Schneider, Clara Rolfs, Matthias Trumpp, Susann Winter, Luise Fischer… in Leukemia (2023)

Article

Estimating prognostic relevant cutoff values for a multiplex PCR detecting BCR::ABL1 in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy in resource-limited settings

The prognosis of chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) treatment is based on the quantification of BCR::ABL1 fusion gene transcript copy number, harmonized by an international scale...

Saifu Hailu, Samuel Kinde, Michael Cross, Aster Tsegaye… in Annals of Hematology (2023)

Article

Optimized production, purification, and radiolabeling of the ²⁰³Pb/²¹²Pb theranostic pair for nuclear medicine

TRIUMF is one of the only laboratories in the world able to produce both lead-203 (²⁰³Pb, t_1/2 = 51.9 h) and ²¹²Pb (t_1/2 = 10.6 h) onsite via its 13 and 500 MeV cyclotrons, respectively. Together, ²⁰³Pb and ²¹²Pb...

Brooke L. McNeil, Simona A. Mastroianni, Scott W. McNeil… in Scientific Reports (2023)

Article

Different treatment strategies versus a common standard arm (CSA) in patients with newly diagnosed AML over the age of 60 years: a randomized German inter-group study

A randomized inter-group trial comparing more intensive treatment strategies to a common standard arm 3 + 7 (CSA) was conducted in patients with non-M3 AML. Untreated patients ≥ 60 years were allocated to the ...

Dietger Niederwieser, Thomas Lang, Rainer Krahl, Thomas Heinicke… in Annals of Hematology (2023)

Article

Clonal hematopoiesis and cardiovascular disease: deciphering interconnections

Cardiovascular and oncological diseases represent the global major causes of death. For both, a novel and far-reaching risk factor has been identified: clonal hematopoiesis (CH). CH is defined as clonal expans...

Anna Stein, Klaus Metzeler, Anne Sophie Kubasch… in Basic Research in Cardiology (2022)

Article

Prospective phase II study of preemptive chimerism-driven reduction of immunosuppression after non-myeloablative conditioning—Eudract #: 2007-002420-15

Saskia Hell, Madlen Jentzsch, Georg-Nikolaus Franke… in Bone Marrow Transplantation (2022)

Article

Correction to: Allogeneic hematopoietic stem cell transplantation improves long‑term outcome for relapsed AML patients across all ages: results from two East German Study Group Hematology and Oncology (OSHO) trials

Thomas Heinicke, Rainer Krahl, Christoph Kahl, Michael Cross… in Annals of Hematology (2021)

Article

Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells

The bone marrow microenvironment (BMME) plays a key role in the pathophysiology of myelodysplastic syndromes (MDS), clonal blood disorders affecting the differentiation, and maturation of hematopoietic stem an...

Manja Wobus, Anna Mies, Nandini Asokan, Uta Oelschlägel, Kristin Möbus… in Leukemia (2021)

Article

Allogeneic hematopoietic stem cell transplantation improves long-term outcome for relapsed AML patients across all ages: results from two East German Study Group Hematology and Oncology (OSHO) trials

Relapse of acute leukemia is a frequent complication with uncertain outcome and poorly defined risk factors. From 1621 patients entered into two prospective clinical trials (AML02; n = 740 and AML04; n = 881),...

Thomas Heinicke, Rainer Krahl, Christoph Kahl, Michael Cross… in Annals of Hematology (2021)

Article

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([⁶⁸Ge]Ge/[⁶⁸Ga]Ga) generators are incapable of supplying sufficient amounts of the short-lived daughter isotope. In this study, ...

Helge Thisgaard, Joel Kumlin, Niels Langkjær… in EJNMMI Radiopharmacy and Chemistry (2021)

Article

Inequities in German research system

Michael Cross in Nature (1999)