6 Result(s)
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Article
Open AccessActivation of distinct inflammatory pathways in subgroups of LR-MDS
Aberrant innate immune signaling has been identified as a potential key driver of the complex pathophysiology of myelodysplastic neoplasms (MDS). This study of a large, clinically and genetically well-characte...
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Article
Open AccessProspective phase II study of preemptive chimerism-driven reduction of immunosuppression after non-myeloablative conditioning—Eudract #: 2007-002420-15
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Article
Open AccessLuspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells
The bone marrow microenvironment (BMME) plays a key role in the pathophysiology of myelodysplastic syndromes (MDS), clonal blood disorders affecting the differentiation, and maturation of hematopoietic stem an...
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Article
Clinical impact of clonal hematopoiesis in acute myeloid leukemia patients receiving allogeneic transplantation
Age-related somatic mutations linked to clonal hematopoiesis have been found in apparently healthy individuals and increase the risk of develo** hematologic malignancies. In acute myeloid leukemia (AML) the ...
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Prognostic relevance of DNMT3A R882 mutations in AML patients undergoing non-myeloablative conditioning hematopoietic stem cell transplantation
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Article
TNP-470 fails to block the onset of angiogenesis and early tumor establishment in an intravital minimal disease model
The angiogenesis inhibitor TNP-470 (AGM-1470) has shown encouraging results in animal models of established tumors. However, results of recent clinical trials using TNP-470 have been disappointing. Since littl...
