4 Result(s)
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Michael C Hodder
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessOncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we de...
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Article
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling1, but reduced secretion...
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Article
Open AccessAuthor Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
The original version of this Article contained an error in the spelling of the author Miryam Müller, which was incorrectly given as Miryam Müeller. This has now been corrected in both the PDF and HTML versions...
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Article
Open AccessLoss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that oncogenic Wnt signalling could be specifically targeted ...
