4 Result(s)

Article

Previous radiotherapy improves treatment responses and causes a trend toward longer time to progression among patients with immune checkpoint inhibitor-related adverse events

Immune-related adverse events (irAEs) are frequently encountered by patients during immune checkpoint inhibitor (ICI) treatment and are associated with better treatment outcomes. The sequencing of radiotherapy...

Anna Jokimäki, Henna Hietala, Jasmiini Lemma… in Cancer Immunology, Immunotherapy (2023)

Article

Evolution and modulation of antigen-specific T cell responses in melanoma patients

Analyzing antigen-specific T cell responses at scale has been challenging. Here, we analyze three types of T cell receptor (TCR) repertoire data (antigen-specific TCRs, TCR-repertoire, and single-cell RNA + TC...

Jani Huuhtanen, Liang Chen, Emmi Jokinen, Henna Kasanen… in Nature Communications (2022)

Article

Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients

Anti-PD1 treatment has improved the survival of metastatic melanoma patients, yet it is unknown which patients benefit from the treatment. In this exploratory study, we aimed to understand the effects of anti-...

Henna Kasanen, Micaela Hernberg, Siru Mäkelä… in Cancer Immunology, Immunotherapy (2020)

Article

Nivolumab improved survival vs dacarbazine in patients with untreated advanced melanoma

Georgina V Long, Victoria Atkinson, Paolo A Ascierto… in Journal of Translational Medicine (2015)