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Article
Open AccessClinical profile and treatment outcomes of idiopathic intracranial hypertension: a multicenter study from Korea
Currently, there is a relative lack of detailed reports regarding clinical presentation and outcome of idiopathic intracranial hypertension in Asians. This study aims to describe the clinical features and trea...
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Article
Reversible cerebral vasoconstriction syndrome in Guillain-Barre syndrome: a case report and literature review
Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by transient constriction of cerebral arteries, leading to severe headache and potential complications. The association between RCVS and Gu...
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Article
Open AccessComparative analyses of the faecal resistome against β-lactam and quinolone antibiotics in humans and livestock using metagenomic sequencing
To assess the prevalence and abundance of antibiotic resistance genes in human and livestock gut microbiomes, 87 humans (healthy individuals and patients with Clostridioides difficile infection (CDI)) and 108 liv...
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Article
Production of autolysis-proof Kex2 protease from Candida albicans in Saccharomyces cerevisiae for in vitro processing of fusion proteins
Protein expression with a fusion partner followed by the removal of the fusion partner via in vitro processing with a specific endoprotease is a favored method for the efficient production of intact recombinan...
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Article
Open AccessThe Korean undiagnosed diseases program phase I: expansion of the nationwide network and the development of long-term infrastructure
Phase I of the Korean Undiagnosed Diseases Program (KUDP), performed for 3 years, has been completed. The Phase I program aimed to solve the problem of undiagnosed patients throughout the country and develop i...
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Article
Open AccessPRE-OPerative ECHOcardiograhy for prevention of cardiovascular events after non-cardiac surgery in intermediate- and high-risk patients: protocol for a low-interventional, mixed-cohort prospective study design (PREOP-ECHO)
Cardiac evaluation using transthoracic echocardiography before noncardiac surgery is common in real-world practice. However, evidence supporting preoperative echocardiography is lacking. This study aims to eva...
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Article
Open AccessPRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression
Although stromal fibroblasts play a critical role in cancer progression, their identities remain unclear as they exhibit high heterogeneity and plasticity. Here, a master transcription factor (mTF) constructin...
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Article
Korean red ginseng extract exploits NF-κB to promote wound repair and protein expression in keratinocytes
Keratinocytes are the primary cell type in the epidermis and play an essential role in protecting the body against external insults. To investigate the modulatory potential of Korean red ginseng (KRG) on kerat...
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Article
Open AccessRelationship between the appropriateness of antibiotic treatment and clinical outcomes/medical costs of patients with community-acquired acute pyelonephritis: a multicenter prospective cohort study
Inappropriate use of antibiotics not only increases antibiotic resistance as collateral damage but also increases clinical failure rates and medical costs. The purpose of this study was to determine the relati...
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Article
Secretome-based screening of fusion partners and their application in recombinant protein secretion in Saccharomyces cerevisiae
For the efficient production of heterologous proteins in the yeast Saccharomyces cerevisiae, we screened for a novel fusion partner from the yeast secretome. From twenty major proteins identified from the yeast s...
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Article
Open AccessA novel protein fusion partner, carbohydrate-binding module family 66, to enhance heterologous protein expression in Escherichia coli
Proteins with novel functions or advanced activities developed by various protein engineering techniques must have sufficient solubility to retain their bioactivity. However, inactive protein aggregates are fr...
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Article
Open AccessDirected evolution and secretory expression of xylose isomerase for improved utilisation of xylose in Saccharomyces cerevisiae
Xylose contained in lignocellulosic biomass is an attractive carbon substrate for economically viable conversion to bioethanol. Extensive research has been conducted on xylose fermentation using recombinant Sacch...
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Article
Open AccessBlood pressure levels and cardiovascular risk according to age in patients with diabetes mellitus: a nationwide population-based cohort study
Little is known about age-specific target blood pressure (BP) in hypertensive patients with diabetes mellitus (DM). The aim of this study was to determine the BP level at the lowest cardiovascular risk of hype...
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Article
Open AccessDiagnosis of thyroid nodules on ultrasonography by a deep convolutional neural network
The purpose of this study was to evaluate and compare the diagnostic performances of the deep convolutional neural network (CNN) and expert radiologists for differentiating thyroid nodules on ultrasonography (...
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Article
Multi-tissue lipotoxicity caused by high-fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice
Excessive intake of fat, one of the causes of obesity, is associated with low-grade inflammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppre...
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Article
Open AccessReliability of Physiological Responses Induced by Basic Emotions: A Pilot Study
Although emotion-specific autonomic responses based on the discrete theory of emotion have been widely studied, studies on the reliability of physiological responses to emotional stimuli are limited. In this s...
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Article
Open AccessDirect Production of Difructose Anhydride IV from Sucrose by Co-fermentation of Recombinant Yeasts
A functional sweetener, difructose anhydride IV (DFA IV), is enzymatically produced from sucrose via levan by levansucrase (LSRase) followed by levan fructotransferase (LFTase). Here, we have demonstrated a co...
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Article
Efficient production of levan using a recombinant yeast Saccharomyces cerevisiae hypersecreting a bacterial levansucrase
Levan is a fructose polymer with diverse applications in the food and medical industries. In this study, levansucrase from Rahnella aquatilis (RaLsrA) was hyper-secreted using a Saccharomyces cerevisiae protein s...
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Article
Analysis of the Relationship among Flood Severity, Precipitation, and Deforestation in the Tonle Sap Lake Area, Cambodia Using Multi-Sensor Approach
Cambodia is the 9th country in the world to be vulnerable to natural disasters in 2011, especially due to the storm and flood. Also, it is worrisome that there is a rapid deforestation in Cambodia, which can be a...
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Article
The efficacy of intracerebroventricular idursulfase-beta enzyme replacement therapy in mucopolysaccharidosis II murine model: heparan sulfate in cerebrospinal fluid as a clinical biomarker of neuropathology
Mucopolysaccharidosis II (MPS II) is caused by a deficiency of iduronate-2-sulfatase that results in accumulation of glycosaminoglycans (GAG), including heparan sulfate (HS), which is considered to contribute ...
