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Cardiac Surgery
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Article
Open AccessComparative analysis of del Nido cardioplegia versus blood cardioplegia in isolate coronary artery bypass grafting
This study examined the efficacy of del Nido cardioplegia compared with traditional blood cardioplegia in adult cardiac surgery for isolated coronary artery bypass grafting by evaluating the early postoperativ...
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Open AccessSuccessful open surgical treatment for persistent type II endoleak following thoracic endovascular aortic repair: a case report
The occurrence of type II endoleaks after endovascular repair of aortic aneurysm has gradually gained increasing attention. We present a case of a patient with an expanding aneurysm after thoracic endovascular...
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Article
Aficamten reduces symptoms in obstructive hypertrophic cardiomyopathy
Data from the SEQUOIA-HCM trial show that aficamten, a cardiac myosin inhibitor, increases exercise capacity and improves quality of life in patients with symptomatic obstructive hypertrophic cardiomyopathy.
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RNA interference lowers triglyceride levels
Data from the phase IIb MUIR and ARCHES-2 trials show that RNA interference approaches that target either apolipoprotein C-III or ANGPTL3 significantly reduce plasma triglyceride levels in patients with mixed ...
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Article
A Novel Mental Health Curriculum Pilot for Pediatric Cardiology Fellows: Preparing the Subspecialist to Expand the Team
Mental health (MH) is an important, yet understudied area of care for patients with congenital heart disease (CHD). Pediatric subspecialty fellows believe MH should be within their scope of practice, but few f...
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No benefit of apoA-I infusion after myocardial infarction
In the AEGIS-II trial, infusion of apolipoprotein A-I to increase cholesterol efflux capacity did not improve outcomes in patients with acute myocardial infarction.
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Periodontal treatment reduces AF recurrence
Treatment for periodontal disease might reduce the recurrence of atrial fibrillation (AF) in patients undergoing ablation, suggesting that periodontitis is a modifiable risk factor for AF.
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Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy
According to data from the IMPROVE-HCM trial, ninerafaxstat is well tolerated by patients with symptomatic non-obstructive hypertrophic cardiomyopathy and improves exercise performance among those who are most...
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No benefit of β-blockers after myocardial infarction with preserved ejection fraction
In the REDUCE-AMI trial, the use of β-blockers in patients with acute myocardial infarction (MI) who have undergone early coronary angiography and have a preserved left ventricular ejection fraction did not re...
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Metabolic product of excess niacin is linked to increased risk of cardiovascular events
A metabolic product of excess niacin promotes vascular inflammation in preclinical models and is associated with increased rates of major adverse cardiovascular events in humans.
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Weight loss from surgery or drug therapy reduces blood pressure
Two studies indicate that a reduction in body mass index as a result of either bariatric surgery or pharmacological therapy is associated with a blood pressure-lowering effect.
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Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy
Anti-inflammatory therapy involving IL-1β inhibition might reduce the risk of cardiovascular events in individuals with clonal haematopoiesis by increasing the number of fibroblast-like cells in the fibrous ca...
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PCI for stable angina
In the ORBITA-2 trial, percutaneous coronary intervention was associated with a lower angina symptom score compared with a placebo procedure in patients with stable angina who were receiving minimal or no anti...
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Aspirin exclusion in patients with an LVAD
Data from the ARIES-HM3 trial show that excluding aspirin from the antithrombotic regimen in patients with advanced heart failure and a left ventricular assist device reduces the number of bleeding events and ...
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Levothyroxine supplementation does not improve heart transplantation from brain-dead donors
The use of intravenous levothyroxine does not increase the likelihood of hearts being transplanted from haemodynamically unstable, brain-dead potential donors, suggesting that current practice recommendations ...
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Explaining how a cardiac reflex causes syncope
Activation of a specific set of vagal sensory neurons connecting the ventricular wall of the heart to the area postrema in the brainstem causes mice to faint. This finding defines a cardiac reflex that recapit...
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Revealing the structure of the cardiac myosin filament
Two new studies using cryo-electron microscopy describe the structure and conformation of myosin in the cardiac thick filaments and how it interacts with other thick-filament proteins, such as titin and cardia...
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Percutaneous Mitral Valve Repair in Pediatric Patients
Rigorous clinical trials have demonstrated the safety and efficacy of Transcatheter Edge-to-Edge Repair to treat severe secondary mitral regurgitation (MR) in adults with primary cardiomyopathy who have failed...
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SARS-CoV-2 infects macrophages in coronary atherosclerotic plaques
SARS-CoV-2 infects macrophages, especially lipid-laden foam cells, in coronary atherosclerotic plaques in patients with COVID-19; this infection initiates a strong proatherogenic inflammatory response, which m...
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Delving into New Frontiers: assessing ChatGPT’s proficiency in revealing uncharted dimensions of general surgery and pinpointing innovations for future advancements
The advent of artificial intelligence (AI) has significantly influenced various medical domains, including general surgery. This research aims to assess ChatGPT, an AI language model, in its ability to shed li...
