438 Result(s)
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Mi** Lim
Medicine & Public Health
English
Cardiac Imaging
Medicine/Public Health, general
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Article
Aficamten reduces symptoms in obstructive hypertrophic cardiomyopathy
Data from the SEQUOIA-HCM trial show that aficamten, a cardiac myosin inhibitor, increases exercise capacity and improves quality of life in patients with symptomatic obstructive hypertrophic cardiomyopathy.
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Article
RNA interference lowers triglyceride levels
Data from the phase IIb MUIR and ARCHES-2 trials show that RNA interference approaches that target either apolipoprotein C-III or ANGPTL3 significantly reduce plasma triglyceride levels in patients with mixed ...
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Article
No benefit of apoA-I infusion after myocardial infarction
In the AEGIS-II trial, infusion of apolipoprotein A-I to increase cholesterol efflux capacity did not improve outcomes in patients with acute myocardial infarction.
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Periodontal treatment reduces AF recurrence
Treatment for periodontal disease might reduce the recurrence of atrial fibrillation (AF) in patients undergoing ablation, suggesting that periodontitis is a modifiable risk factor for AF.
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Article
Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy
According to data from the IMPROVE-HCM trial, ninerafaxstat is well tolerated by patients with symptomatic non-obstructive hypertrophic cardiomyopathy and improves exercise performance among those who are most...
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Article
No benefit of β-blockers after myocardial infarction with preserved ejection fraction
In the REDUCE-AMI trial, the use of β-blockers in patients with acute myocardial infarction (MI) who have undergone early coronary angiography and have a preserved left ventricular ejection fraction did not re...
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Article
Metabolic product of excess niacin is linked to increased risk of cardiovascular events
A metabolic product of excess niacin promotes vascular inflammation in preclinical models and is associated with increased rates of major adverse cardiovascular events in humans.
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Article
Weight loss from surgery or drug therapy reduces blood pressure
Two studies indicate that a reduction in body mass index as a result of either bariatric surgery or pharmacological therapy is associated with a blood pressure-lowering effect.
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Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy
Anti-inflammatory therapy involving IL-1β inhibition might reduce the risk of cardiovascular events in individuals with clonal haematopoiesis by increasing the number of fibroblast-like cells in the fibrous ca...
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Article
PCI for stable angina
In the ORBITA-2 trial, percutaneous coronary intervention was associated with a lower angina symptom score compared with a placebo procedure in patients with stable angina who were receiving minimal or no anti...
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Article
Aspirin exclusion in patients with an LVAD
Data from the ARIES-HM3 trial show that excluding aspirin from the antithrombotic regimen in patients with advanced heart failure and a left ventricular assist device reduces the number of bleeding events and ...
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Article
Levothyroxine supplementation does not improve heart transplantation from brain-dead donors
The use of intravenous levothyroxine does not increase the likelihood of hearts being transplanted from haemodynamically unstable, brain-dead potential donors, suggesting that current practice recommendations ...
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Article
Explaining how a cardiac reflex causes syncope
Activation of a specific set of vagal sensory neurons connecting the ventricular wall of the heart to the area postrema in the brainstem causes mice to faint. This finding defines a cardiac reflex that recapit...
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Revealing the structure of the cardiac myosin filament
Two new studies using cryo-electron microscopy describe the structure and conformation of myosin in the cardiac thick filaments and how it interacts with other thick-filament proteins, such as titin and cardia...
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Article
SARS-CoV-2 infects macrophages in coronary atherosclerotic plaques
SARS-CoV-2 infects macrophages, especially lipid-laden foam cells, in coronary atherosclerotic plaques in patients with COVID-19; this infection initiates a strong proatherogenic inflammatory response, which m...
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Article
No benefit of colchicine to prevent AF or myocardial injury after non-cardiac surgery
According to data from the COP-AF trial, anti-inflammatory therapy with colchicine does not reduce the risk of perioperative atrial fibrillation or myocardial injury in patients undergoing major non-cardiac th...
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Article
VA-ECMO does not increase survival in MI-related cardiogenic shock
New data from the ECLS-SHOCK trial and a meta-analysis indicate that the routine use of venoarterial extracorporeal membrane oxygenation does not increase survival in patients with myocardial infarction-relate...
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Article
Cholesterol catabolism and bile acid synthesis in cardiomyocytes promote inflammation and heart failure
In failing cardiomyocytes, depletion of carnitine acetyltransferase promotes cholesterol catabolism via the bile acid synthesis pathway. The intracellular accumulation of bile acid intermediates induces the re...
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Article
Testosterone-replacement therapy does not increase cardiac events in men with hypogonadism
Testosterone-replacement therapy in men with hypogonadism and a high risk of cardiovascular disease does not increase the risk of adverse cardiac events, according to data from the TRAVERSE trial.
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Article
Antibody treatment to deplete transthyretin amyloid deposits in the heart
An antibody-based therapy for transthyretin amyloid cardiomyopathy is safe, and initial findings from a phase I trial suggest that it might deplete amyloid deposits in the heart.
