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  1. Article

    Open Access

    Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA

    RNA-guided systems, such as CRISPR–Cas, combine programmable substrate recognition with enzymatic function, a combination that has been used advantageously to develop powerful molecular technologies1,2. Structura...

    Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E. Wilkinson… in Nature (2022)

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    Article

    Structure of a spliceosome remodelled for exon ligation

    The cryo-electron microscopy structure of a yeast spliceosome stalled before mature RNA formation provides insight into the mechanism of exon ligation.

    Sebastian M. Fica, Chris Oubridge, Wojciech P. Galej, Max E. Wilkinson… in Nature (2017)

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    Article

    Cryo-EM structure of the spliceosome immediately after branching

    Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification reactions via a lariat–intron intermediate. Here we present the 3.8 Å cryo-electron microscopy structure of the spliceosome im...

    Wojciech P. Galej, Max E. Wilkinson, Sebastian M. Fica, Chris Oubridge… in Nature (2016)