11 Result(s)
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Matthew Parker
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAuthor Correction: Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation
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Article
Open AccessChromosome evolution and the genetic basis of agronomically important traits in greater yam
The nutrient-rich tubers of the greater yam, Dioscorea alata L., provide food and income security for millions of people around the world. Despite its global importance, however, greater yam remains an orphan cro...
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Article
Improved performance of Eimeria-infected chickens fed corn expressing a single-domain antibody against interleukin-10
Antimicrobial resistance is a significant challenge for human and animal health, and develo** effective antibiotic-free treatments is a strategy to help mitigate microbial resistance. The global poultry indu...
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Article
Open AccessClinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
To evaluate the potential of an integrated clinical test to detect diverse classes of somatic and germline mutations relevant to pediatric oncology, we performed three-platform whole-genome (WGS), whole exome ...
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Open AccessThe m6A-methylase complex recruits TREX and regulates mRNA export
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding ...
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Article
Open AccessCancer-associated DDX3X mutations drive stress granule assembly and impair global translation
DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects of RNA metabolism including translation initiation and the assembly of stress granules (SGs). Recent genomic studies have reported ...
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The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
Studies of paediatric cancers have shown a high frequency of mutation across epigenetic regulators. Here we sequence 633 genes, encoding the majority of known epigenetic regulatory proteins, in over 1,000 paed...
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Correction: Corrigendum: C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma
Nature 506, 451–455 (2014); doi:10.1038/nature13109 In this Article, author Jared Becksfort’s surname was incorrectly spelled ‘Becksford’. Also, his affiliation should be the Department of Computational Biolog...
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C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma
Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is present in most human tumour...
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Open AccessNovel mutations target distinct subgroups of medulloblastoma
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of 37 tumours and matched norma...
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Open AccessThe genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the i...
