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Article
The genomic landscape of pediatric acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low ...
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Chapter
Modeling OCD Endophenotypes in Zebrafish
Obsessive compulsive disorder (OCD) is a pervasive, debilitating neuropsychiatric disorder. Despite over half a century of effort, OCD has remained remarkably resistant to treatment, partly owing to a lack of ...
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Article
Exploring genomic alteration in pediatric cancer using ProteinPaint
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Article
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
Anna Andersson, Tanja Gruber, James Downing and colleagues report a genomic analysis of infant acute lymphoblastic leukemias with MLL rearrangements. They identify recurrent activating mutations in tyrosine kinas...
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Book Series
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Book
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Chapter
Particular Aspects of US Patent Law in Biotechnologies
A patent is defined as an exclusive right or rights provided by a government to an inventor for a certain period of time in exchange for the public disclosure of an invention. Patent protection can be sought i...
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Article
The genomic landscape of hypodiploid acute lymphoblastic leukemia
Linda Holmfeldt, Lei Wei et al. report whole-genome and exome sequencing of 40 childhood hypodiploid acute lymphoblastic leukemias.