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Article

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution

Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-mutation-driven clonal evolution and subsequent transformation is a crucial step toward the design of rational therapeutic strategi...

Alba Rodriguez-Meira, Ruggiero Norfo, Sean Wen, Agathe L. Chédeville… in Nature Genetics (2023)