37 Result(s)

Article

Proposal of criteria for dyserythropoiesis in the diagnosis of myelodysplastic syndromes

The percentage manifesting dysplasia in bone marrow needed to qualify as significant is ≥10 % in each lineage. However, detailed analyses of this threshold have not been reported. Here, we analyzed dyserythrop...

Nobutaka Kawai, Akira Matsuda, Itsuro **nai… in International Journal of Hematology (2016)

Article

Long-term outcome of immunosuppressive therapy for Japanese patients with lower-risk myelodysplastic syndromes

To investigate the long-term usefulness of immunosuppressive therapy (IST) for Japanese patients with lower-risk myelodysplastic syndromes, we retrospectively analyzed 29 MDS patients who were treated with cyc...

Tomoko Hata, Hideki Tsushima, Maki Baba… in International Journal of Hematology (2013)

Article

Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa

The T315I BCR-ABL mutation in chronic myelogenous leukemia (CML) patients is responsible for up to 20% of all clinically observed resistance. This mutation confers resistance not only to imatinib, but also to ...

Hidehiro Itonaga, Hideki Tsushima, Tomoko Hata… in International Journal of Hematology (2012)

Article

Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts

The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts ...

Shinya Tominaga-Sato, Hideki Tsushima, Koji Ando… in International Journal of Hematology (2011)

Article

Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size: a report by the Nagasaki CML Study Group

Imatinib has dramatically improved long-term survival of chronic myelogenous leukemia (CML) patients. To analyze its efficacy in a practical setting, we registered most of CML patients in Nagasaki Prefecture o...

Mari Sakai, Yasushi Miyazaki, Emi Matsuo… in International Journal of Hematology (2009)

Chapter and Conference Paper

Leukemia, Lymphoma, and Multiple Myeloma Incidence in the LSS Cohort: 1950–2001

Leukemia was one of the first late health effects of radiation exposure observed among the atomic bomb survivors, initially appearing in the late 1940s. Several Atomic Bomb Casualty Commission/Radiation Effect...

Wan-Ling Hsu, Midori Soda, Nobuo Nishi, Dale Preston… in Radiation Health Risk Sciences (2009)

Article

Successful cord blood transplantation for mycosis fungoides

A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity ...

Takuya Fukushima, Kensuke Horio, Emi Matsuo… in International Journal of Hematology (2008)

Article

Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein: a novel in vitro model of the growth of acute ATL cells

In order to better understand the biology of adult T cell leukemia (ATL), we aimed to establish a novel method, which allows the primary growth of ATL cells using a co-culture system with murine bone marrow-de...

Kazuhiro Nagai, Itsuro **nai, Tomoko Hata… in International Journal of Hematology (2008)

Article

Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes

Many patients with bone marrow failure syndromes need frequent transfusions of red blood cells, and most of them eventually suffer from organ dysfunction induced by excessively accumulated iron. The only way t...

Takahiro Suzuki, Masao Tomonaga, Yasushi Miyazaki… in International Journal of Hematology (2008)

Article

Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol

We reviewed and categorized 638 of 809 patients who were registered in the Japan Adult Leukemia Study Group acute myeloid leukemia (AML)-97 protocol using morphological means. Patients with the M3 subtype were...

Moe Wakui, Kazutaka Kuriyama, Yasushi Miyazaki… in International Journal of Hematology (2008)

Article

The echocardiographic Tei-index reflects early myocardial damage induced by anthracyclines in patients with hematological malignancies

Anthracyclines are antineoplastic agents that are effective against solid tumors and hematological malignancies. However, drug-induced cardiotoxicity imposes dose limitations. Myocardial damage due to anthracy...

Norihiko Senju, Satoshi Ikeda, Seiji Koga, Yoshiyuki Miyahara… in Heart and Vessels (2007)

Article

Imatinib provides durable molecular and cytogenetic responses in a practical setting for both newly diagnosed and previously treated chronic myelogenous leukemia: a study in Nagasaki prefecture, Japan

To evaluate the efficacy of imatinib in a practical setting, we registered 43 patients with newly diagnosed chronic myelogenous leukemia (CML) (group I) and 56 patients with previously diagnosed CML (group II)...

Emi Matsuo, Yasushi Miyazaki, Chizuko Tsutsumi… in International Journal of Hematology (2007)

Article

Myelodysplastic Syndrome

Shinji Nakao, H. Joachim Deeg, Takayuki Ishikawa… in International Journal of Hematology (2005)

Article

A Novel Plasmacytoid Dendritic Cell Line, CAL-1, Established from a Patient with Blastic Natural Killer Cell Lymphoma

Blastic natural killer (NK) cell lymphoma corresponding to CD4+CD56+ malignancies is a novel disease entity, according to the results of clinical, morphologic, and immunologic studies. It is especially notewor...

Takahiro Maeda, Kenn Murata, Takuya Fukushima… in International Journal of Hematology (2005)