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  1. No Access

    Article

    A complement-dependent cytotoxicity-enhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγnull mouse lymphoma model

    Engineering the Fc region of monoclonal antibodies (mAb) in order to enhance effector functions such as antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity (CDC) is likely to a be pr...

    Fumihiko Sato, Asahi Ito, Takashi Ishida, Fumiko Mori… in Cancer Immunology, Immunotherapy (2010)

  2. Article

    Open Access

    Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse model

    There are no suitable small animal models to evaluate human antibody-dependent cellular cytotoxicity (ADCC) in vivo, due to species incompatibilities. Thus, the first aim of this study was to establish a human...

    Asahi Ito, Takashi Ishida, Hiroki Yano, Atsushi Inagaki… in Cancer Immunology, Immunotherapy (2009)

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