10 Result(s)
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Chapter
Pangenomes and Selection: The Public Goods Hypothesis
The evolution and structure of prokaryotic genomes are largely shaped by horizontal gene transfer. This process is so prevalent that DNA can be seen as a public good—a resource that is shared across individua...
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Article
Open AccessErratum to: Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins
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Article
Open AccessErratum to: Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response
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Open AccessSurface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response
Clostridium difficile is a nosocomial pathogen prevalent in hospitals worldwide and increasingly common in the community. Sequence differences have been shown to be present in the Surf...
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Article
Open AccessMolecular adaptation of telomere associated genes in mammals
Placental mammals display a huge range of life history traits, including size, longevity, metabolic rate and germ line generation time. Although a number of general trends have been proposed between these trai...
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Article
Open AccessColon cancer associated genes exhibit signatures of positive selection at functionally significant positions
Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider t...
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Selection and the Cell Cycle: Positive Darwinian Selection in a Well-Known DNA Damage Response Pathway
Cancer is a common occurrence in multi-cellular organisms and is not strictly limited to the elderly in a population. It is therefore possible that individuals with genotypes that protect against early onset c...
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Open AccessPositive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins
Reproductive proteins are central to the continuation of all mammalian species. The evolution of these proteins has been greatly influenced by environmental pressures induced by pathogens, rival sperm, sexual ...
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Article
Open AccessThe phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions
The mammalian heme peroxidases (MHPs) are a medically important group of enzymes. Included in this group are myeloperoxidase, eosinophil peroxidase, lactoperoxidase, and thyroid peroxidase. These enzymes are a...
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Article
Gamma Chain Receptor Interleukins: Evidence for Positive Selection Driving the Evolution of Cell-to-Cell Communicators in the Mammalian Immune System
The interleukin-2 receptor (IL-2R) γ chain, or common γ chain (γc), is the hub of a protein interaction network in the mammalia that is central to defense against disease. It is the indispensable subunit of th...
