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Article
The SARD variety of multifractality of ventricular epicardial map** during ischemia
We have analyzed cardiac ischemia-reperfusion in an animal model using epicardial electropotential map**. We investigated the relationship between ischemia and variability of multifractality in epicardial el...
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Chapter and Conference Paper
Towards Tracking Breast Cancer Across Medical Images Using Subject-Specific Biomechanical Models
Breast cancer detection, diagnosis and treatment increasingly involves images of the breast taken with different degrees of breast deformation. We introduce a new biomechanical modelling framework for predicti...
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Chapter and Conference Paper
Passive Ventricular Mechanics Modelling Using MRI of Structure and Function
Patients suffering from dilated cardiomyopathy or myocardial infarction can develop left ventricular (LV) diastolic impairment. The LV remodels its structure and function to adapt to pathophysiological changes...
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Chapter and Conference Paper
Modelling Mammographic Compression of the Breast
We have developed a biomechanical model of the breast to simulate compression during mammographic imaging. The modelling framework was applied to a set of MR images of the breasts of a volunteer. Images of the...
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Chapter and Conference Paper
The Breast Biomechanics Reference State for Multi-modal Image Analysis
Multi-modality imaging of the breast is becoming increasingly common, and yet combining the information from the different images is difficult due to differences in the basic imaging physics, geometry, and the...
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Chapter and Conference Paper
Modelling Childbirth: Comparing Athlete and Non-athlete Pelvic Floor Mechanics
There is preliminary evidence that athletes involved in high-intensity sports for sustained periods have a higher probability of experiencing a prolonged second stage of labour compared to non-athletes. The me...
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Chapter and Conference Paper
Interactive Cardiac Image Analysis for Biventricular Function of the Human Heart
We developed an interactive tool for biventricular function analysis from cardiac magnetic resonance (MR) images based on the guide point modelling (GPM) approach [1]. First we built a deformable model of both...
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Chapter and Conference Paper
Map** Microcalcifications Between 2D Mammograms and 3D MRI Using a Biomechanical Model of the Breast
We propose a method to localise the 3D positions of microcalcifications found in X-ray mammograms using the 3D breast modelling framework of Chung et al. [1]. The accuracy of the method was first studied using...
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Chapter and Conference Paper
Investigating Heart Failure Using Ventricular Imaging and Modelling
It is well-established that ventricular hypertrophy is a transitional phase through the development of heart failure. A hypertrophic heart can remodel to compensate the loss of pump function, but it eventually...
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Chapter and Conference Paper
Method for Validating Breast Compression Models Using Normalised Cross-Correlation
To diagnose and manage breast cancer, X-ray mammography, ultrasound, and magnetic resonance (MR) imaging are used to image the breasts. In this chapter, we present a method for validating finite element (FE) b...
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Chapter and Conference Paper
Breast Image Registration by Combining Finite Elements and Free-Form Deformations
During breast cancer diagnosis, the breasts undergo large deformations due to gravity or compression loads. It is therefore non-trivial to recover the deformation and register medical images of the breast in d...
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Chapter and Conference Paper
Effects of Fetal Head Motion on Pelvic Floor Mechanics
We have developed a modelling framework to simulate vaginal delivery using individual-specific pelvic floor geometries derived from magnetic resonance images, which could potentially be used to study the effec...
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Chapter and Conference Paper
Cardiac Active Contraction Parameters Estimated from Magnetic Resonance Imaging
Impaired systolic ventricular function is common in patients diagnosed with heart failure (HF) or ischaemic heart disease. The diminished contractile performance with impaired contractility (systolic HF) can b...
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Reference Work Entry In depth
The Inverse Problem of Electrocardiography
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Article
Open AccessInteractive biventricular modeling tools for clinical cardiac image analysis
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Chapter and Conference Paper
Map** Breast Cancer Between Clinical X-Ray and MR Images
Characterizing a breast lesion can involve comparing X-ray and magnetic resonance (MR) images of a patient’s breast. Tracking a lesion between these imaging modalities is nontrivial because of the different ty...
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Chapter and Conference Paper
A Quantitative Description of Pelvic Floor Muscle Fibre Organisation
The levator ani (LA) muscles play an important role in pelvic floor function. With the aid of computer models and mechanics simulations, the injury mechanism of LA muscles can be better understood to prevent p...
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Article
Anisotropic effects of the levator ani muscle during childbirth
Pelvic floor dysfunction and pelvic organ prolapse have been associated with damage to the levator ani (LA) muscle, but the exact mechanisms linking them remain unknown. It has been postulated that factors suc...
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Article
Estimating material parameters of a structurally based constitutive relation for skin mechanics
This paper presents a structurally based modeling framework to characterize the structure–function relation in skin tissues, based upon biaxial tensile experiments performed in vitro on porcine skin. Equi-axia...
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Article
Predicting lymphatic drainage patterns and primary tumour location in patients with breast cancer
Detailed knowledge of the lymphatic drainage of the breast is limited. Lymphoscintigraphy is a technique used during breast cancer treatment to accurately map patterns of lymphatic drainage from the primary tu...