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  1. Article

    Open Access

    Galiellalactone inhibits the STAT3/AR signaling axis and suppresses Enzalutamide-resistant Prostate Cancer

    Most prostate cancer patients will progress to a castration-resistant state (CRPC) after androgen ablation therapy and despite the development of new potent anti-androgens, like enzalutamide (ENZ), which prolo...

    Daksh Thaper, Sepideh Vahid, Ramandeep Kaur, Sahil Kumar in Scientific Reports (2018)

  2. Article

    Open Access

    Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice

    Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, representing approximately 75% of all renal neoplasms. ccRCC is known to be strongly associated with silencing of the von Hippe...

    Elinn Johansson, Birgitte Rönö, Martin Johansson, David Lindgren in Scientific Reports (2016)

  3. Article

    Open Access

    TRPV4 Regulates Breast Cancer Cell Extravasation, Stiffness and Actin Cortex

    Metastasis is a significant health issue. The standard mode of care is combination of chemotherapy and targeted therapeutics but the 5-year survival rate remains low. New/better drug targets that can improve o...

    Wen Hsin Lee, Lee Yee Choong, Naing Naing Mon, SsuYi Lu, Qingsong Lin in Scientific Reports (2016)